Design and Modification of Anticancer Peptides
نویسندگان
چکیده
منابع مشابه
Design and Modification of Anticancer Peptides
Cancer is a great concern in the public health and development of novel therapeutic agent or strategy become urgently. Anticancer peptides (ACPs) have become promising anticancer drug candidate molecules due to their several extraordinary properties, such as small size, high activity, low immunogenicity, good biocompatibility, diversity of sequence and more modification sites for the functional...
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Cancer is one of the causes of death in the world. Several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. Since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. Antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...
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HPRP-A1 is an amphipathic α-helical anticancer peptide (ACP) derived from the N-terminus of ribosomal protein L1 (RpL1) of Helicobacter pylori. In our previously study, HPRP-A1 has been reported that induced HeLa cell apoptosis in a caspase-dependent approach and involved both by the death receptor 'extrinsic' pathway and the mitochondria 'intrinsic' pathway. Here we report the construction of ...
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1 Oral Health Cooperative Research Centre, Melbourne Dental School, University of Melbourne, Parkville, VIC, Australia, 2 Bio21 Institute, University of Melbourne, Parkville, VIC, Australia, 3 Faculty of Chemistry and Mineralogy, Institute of Bioanalytical Chemistry, Universität Leipzig, Leipzig, Germany, 4 Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany, 5 Exper...
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Linear helical channel-forming peptides structurally similar to the Xenopus-derived antibiotic, Magainin2-amide, were synthesized. Because activity resides in the physicochemical properties of the peptides, an all-D-amino acid as well as an all-L-amino acid sequence were tested for anticancer activity. In vitro activity against carcinoma cells and in vivo efficacy against four murine ascites tu...
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ژورنال
عنوان ژورنال: Drug Designing: Open Access
سال: 2016
ISSN: 2169-0138
DOI: 10.4172/2169-0138.1000138